An assay for the detection of bacterial DNA gyrase inhibitors.
نویسندگان
چکیده
In summary, we have developed a sensitive detection system for inhibitors of bacterial DNA gyrase. The use of B. subtilis as the host organism confers the advantage that it is sensitive to both gyrase subunit A and B inhibitors, whereas E. coli is relatively insensitive to B subunit inhibitors in vivo. Using this assay, we identified a new DNA gyrase inhibitor with a novel structure.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 46 11 شماره
صفحات -
تاریخ انتشار 1993